As more wastewater treatment facilities are facing elevated levels of organic contaminants, such as per- and polyfluoroalkyl substances (PFAS), the need for effective industrial pretreatment rises. Currently, there are no conventional treatment technologies that can simultaneously treat all organic contaminants present across the diverse industrial wastewaters due to the differences in their physico-chemical properties (e.g. structure, molecular size, polarity, etc). However, there is a growing demand from municipal and industrial facilities alike for enhanced wastewater infrastructure and innovative technologies that can effectively treat today’s and tomorrow’s organic contaminants. Supercritical water oxidation (SCWO) is one applicable technology that uses a physical thermal process that completely eliminates organic compounds indiscriminately. During SCWO, a waste with an appropriate water:waste:oxygen ratio is fed into a reactor, where temperature and pressure conditions are elevated above the critical point of water (374°C and 221 bar) so that the water in the feed becomes supercritical. The high solubility of organics and gases (e.g. oxygen) in supercritical water allows for the rapid exothermic oxidation of any organic compound, yielding only inert inorganics, recoverable heat, and clean vent gas as the final products. A US based SCWO provider tested their system’s ability to treat HQ-115, 40 PFAS compounds, and pharmaceutical waste containing active pharmaceutical ingredients and 15+ organic solvents to showcase the capability of SCWO to treat a wide range of industrial wastes. These persistent and toxic compounds were selected because they’re increasingly found in the water/wastewater network and are diverse in their properties. Notably, these analytes represent different architectures (linear, branched, cyclic), molecular weights and sizes, and polarities. These contaminants were deemed suitable for destruction via SCWO because they are all organic (i.e. have at least one carbon-carbon or carbon-hydrogen bond). This presentation will provide an in-depth technical discussion of the fundamentals of SCWO that provides a basis for being able to treat these organics and then showcase the corroborating study results that demonstrate >99% removal. A roadmap to implementing SCWO at scale for industrial wastewater will be presented, and concluded with a projection in reductions receiving wastewater plants may see as a result of enhanced industrial pretreatment.