Effectively managing PFAS contamination requires a detailed, science-based approach tailored to the unique challenges of each site. The process begins with thorough site investigations to identify contamination sources and quantify PFAS concentrations in soil, water, and other environmental media. Advanced sampling methods and precise data analysis are employed to ensure accuracy and minimize the potential for cross-contamination. Developing a conceptual site model is a critical next step to understand PFAS movement through the environment and identify exposure pathways. Remediation planning involves evaluating and implementing practical treatment technologies, including granular activated carbon (GAC), ion exchange (IX) media, and membrane systems. While these non-destructive solutions are currently the most viable for large-scale applications, they generate PFAS-laden residuals that require additional management to prevent re-contamination. The need for destructive treatment technologies capable of mineralizing PFAS into stable components, such as carbon dioxide and fluoride ions, is increasingly apparent to address long-term risks. The Stantec Institute of Applied Science, Technology, and Policy has compiled a database of PFAS treatment technologies, detailing both established and emerging solutions across various stages of development. Pilot studies, such as the Minnesota Pollution Control Agency collaboration with Stantec and academic partners, provide essential data on treatment performance and inform regulatory and operational decisions. Notably, Dr. Benjamin Fennell, a lecturer at the University of Tennessee in Knoxville, is conducting significant research on PFAS contamination and treatment methodologies. His work provides crucial insights into the scientific and practical advancements needed for effective PFAS mitigation and offers valuable context for the conference's discussions in Knoxville. Long-term monitoring programs remain essential for assessing progress and refining approaches to meet evolving regulatory standards. By leveraging scientific expertise and engineering innovation, this process delivers effective solutions to mitigate the risks associated with PFAS contamination.